Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2
نویسندگان
چکیده
منابع مشابه
Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2
The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to the homozygous deletion of the gene (GSTM1 null), leading to a lack of corresponding enzymatic activity. Many of these studies have reported inconsistent findings regarding its association with cancer risk. Therefore, we employed in silico, in vitro, and in v...
متن کاملEvaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.
Glutathione S-transferase (GST) enzymes protect cells against xenobiotics and oxidative stress products through an electrophilic conjugation process. We investigated the theta (GSTT1) and mu (GSTM1) null genotypes in a group of leukopenic subjects and normal subjects from Northeast Brazil, evaluating their use as biomarkers of susceptibility for developing leukopenia. In a sample-based case-con...
متن کاملprevalence of null genotypes of glutathione s-transferase t1 (gstt1) and m1 (gstm1) in seven iranian populations
background: previous studies have revealed significant differences between populations for genotypic frequencies of glutathione s-transferase t1 ( gstt1 ) and m1 ( gstm1 ) polymorphisms. in order to find the frequency of the null genotypes of gstm1 and gstt1 in iranian populations, the present study was carried out. methods: the total study subjects consisted of 1340 unrelated healthy muslims/i...
متن کامل"frequency of glutathione s-transferase m1 (gstm1) and gstt1 null genotypes in fars population (south of iran)"
the genes glutathione s-transferase m1 (gstm1) and gstt1 code for cytosolic enzymes gstµ and gstθ, respectively, which are involved in phase ii metabolism. in human, both genes may be deleted. in the present study, the genetic polymorphisms of gstm1 and gstt1 were detected by pcr method in 236 healthy individuals from shiraz population, fars province, south of iran. the frequency of gstm1 and g...
متن کاملPrevalence of Null Genotypes of Glutathione S-Transferase T1 (GSTT1) and M1 (GSTM1) in Seven Iranian Populations
BACKGROUND Previous studies have revealed significant differences between populations for genotypic frequencies of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) polymorphisms. In order to find the frequency of the null genotypes of GSTM1 and GSTT1 in Iranian populations, the present study was carried out. METHODS The total study subjects consisted of 1340 unrelated healthy Muslims/Irani...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep02704